Medical Resources

This section features research related to lipedema, such as the comorbidities normally associated with the disease, and these papers can be downloaded below.

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3.0 T relaxation time measurements of human lymph nodes in adults with and without lymphatic insufficiency – Implications for magnetic resonance lymphatic imaging – R. Crescenzi, P. Donahue, V. Braxton, A. Scott, H. Mahany, S. Lants, M. Donahue (2018)

A PRDM16-driven metabolic signal from adipocytes regulates precursor cell fate – W. Wang, J. Ishibashi1, S. Trefely, M. Shao, A. Cowan, A. Sakers, … & P. Seale (2019)

The carbohydrate-insulin model: A physiological perspective on the obesity pandemic – D. Ludwig, L. Aronne, A. Astrup, R. de Cabo, L. Cantley, M. Friedman, … & C. Ebbeling (2021)

A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease – Z. Chen, R. Yu, Y. Xiong, F. Du, & S. Zhu (2017)

A worm of ones own – How helminths modulate host adipose tissue function and metabolism – B. Guigas & A. Molofsky (2015)

Acupuncture and chiropractic care for chronic pain in an integrated health plan – A mixed study – L. DeBar, C. Elder, C, Ritenbaugh, M. Aickin, R. Deyo, R. Meenan, … & B. Yarborough (2011)

Acupuncture in lymphoedema management – A feasibility study – B. de Valois, T. Young, & E. Melsome

Analytical techniques for serratiopeptidase – A review – V. Gupte & U. Luthra (2017)

Ascorbic acid deficiency impairs wound healing in surgical patients – Four case reports – A. Bikker, J. Wielders, R. van Loo, & M. Loubert (2016)

Bilateral changes in deep tissue environment after manual lymphatic drainage in patients with breast cancer treatment-related lymphedema – P. Donahue, R. Crescenzi, A. Scott, V. Braxton, A. Desai, S. Smith, … & M. Donahue (2017)

Biology of lymphedema – B. Brix, O. Sery, A. Onorato, C. Ure, A. Roessler, & N. Goswami (2021)

Blood pressure measurement challenges in severely obese patients – M. Siddiqui & D. Calhoun (2019)

Blood pressure measurement in obese patients – Comparison between upper arm and forearm measurements – A. Pierin, D. Alavarce, J. Gusmao, A. Halpern, & D. Mion (2004)

Blood pressure measurement in severely obese patients – Validation of the forearm approach in different arm positions – M. Leblanc, A. Auclair, J. Leclerc, J. Bussieres, M. Agharazii, F. Hould, … & P. Poirier (2019)

Blood pressure measurements in obese patients – J. McFarlane (2012)

Breast cancer-related chronic arm lymphedema is associated with excess adipose and muscle tissue – H. Brorson, K. Ohlin, G. Olsson, & M. Karlsson (2009)

CEST MRI quantification procedures for breast cancer treatment-related lymphedema therapy evaluation – R. Crescenzi, P. Donahue, H. Mahany, S. Lants, M. Donahue (2019)

Characterizing lymphangiogenesis and concurrent inflammation in adipose tissue in response to VEGF-D – A. Chakraborty, C. Scogin, K. Rizwan, T. Morley, & J. Rutkowski (2020)

Choline – Its potential role in nonalcoholic fatty liver disease and the case for human and bacterial genes – J. Sherriff, T. O’Sullivan, C. Properzi, J. Oddo, & L. Adams (2016)

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression – K. Corbin & S. Zeisel (2012)

Choline’s role in maintaining liver function – New evidence for epigenetic mechanisms – M. Mehedint & S. Zeisel (2013)

Chronic venous insufficiency – R. Eberhardt & J. Raffetto (2005)

Cochrane summary of findings – Horse chestnut seed extract for chronic venous insufficiency – V. Underland, I. Saeterdal, & E. Nilsen (2012)

Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress – A. Chakraborty, R. Upadhya, T. Usman, A. Shetty, & J. Rutkowski (2021)

Cytokines and fatty liver diseases – L. Niederreiter & H. Tilg (2018)

Dichotomous effects on lymphatic transport with loss of caveolae in mice – G. Baranwal, H. Creed, W. Cromer, W. Wang, B. Upchurch, M. Smithhart, … & J. Rutkowski (2021)

Effects of manual lymphatic drainage on breast cancer-related lymphedema – A systematic review and meta-analysis of randomized controlled trials T. Huang, S. Tseng, C. Lin, C. Bai, C. Chen, C. Hung, … & K. Tam (2013)

Effects of whole-body vibration with or without localized radiofrequency on anthropometry body composition and motor performance in young nonobese women – C. Milanese, F. Piscitelli, C. Simoni, R. Pugliarello, & C. Zancanaro (2012)

Efficacy and safety of a Butcher’s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency – W. Vanscheidt, V. Jost, P. Wolna, P. Lucker, A. Muller, C. Theurer, … & K. Grutzner (2002)

Efficacy of berberine in patients with type 2 diabetes – J. Yina, H. Xinga, & J. Ye (2008)

Elevated magnetic resonance imaging measures of adipose tissue deposition in women with breast cancer treatment-related lymphedema – R. Crescenzi, P. Donahue, M. Garza, C. Lee, N. Patel, V. Gonzalez, R. Jones, & M. Donahue (2021)

Expanded telehealth services offer smart wound care workflows – C. Hess (2020)

OF INTEREST Function of collagens in energy metabolism and metabolic diseases – G. Huang (2014)

Functional and structural impairment of small nerve fibers in patients suffering from hypermobile Ehlers Danlos Syndrome – Hypermobility Spectrum Disorder – A. Fernandez, B. Aubry-Rozier, M. Vautey, C. Berna, & M. Suter (2022)

OF INTEREST Hydrolysis of hyaluronic acid in lymphedematous tissue alleviates fibrogenesis via TH1 cell-mediated cytokine expression – S. Cho, K. Roh, J. Park, Y. Park, M. Lee, S. Cho, … & S. Lee (2017)

Impact of intermittent fasting on health and disease processes – M. Mattson, V. Longo, & M. Harvie (2017)

Implementation of single-tab electrodes for bioimpedance spectroscopy measures – P. Donahue, R. Crescenzi, L. Du, & M. Donahue (2020)

Instrument-assisted soft-tissue mobilization – A commentary on clinical practice guidelines for rehabilitation professionals – S. Cheatham,
R. Baker, & E. Kreiswirth

Insulin resistence disrupts cell integrity, mitochondrial function and inflammatory signaling in lymphatic endothelium – Y. Lee, S. Chakraborty, C. Menininger, & M. Muthuchamy (2018)

Liposuction treatment of lymphedema – M. Schaverien, D. Munnoch, & H. Brorson (2018)

Living life to the fullest with Ehlers-Danlos syndrome – K. Muldowney (2015)

Lymphatic function measurements influenced by contrast agent volume and body position – E. Bouta, C. Blatter, T. Ruggieri, E. Meijer, L. Munn, B. Vakoc, & T. Padera (2018)

Magnesium and inflammation: Advances and perspectives – J. Maier, S. Castiglioni, L. Locatelli, M. Zocchi, & A. Mazur (2021)

Magnetic resonance imaging and bioimpedance evaluation of lymphatic abnormalities in patients with breast cancer treatment-related lymphedema – P. Donahue, R. Crescenzi, C. Lee, M. Garza, N. Patel, K. Petersen, & M. Donahue (2020)

Management of chronic pain in Ehlers–Danlos – Z. Zhou, A. Rewari, & H. Shanthanna (2018)

Manual lymphatic drainage guided by real-time indocyanine green lymphography in breast cancer-related lymphedema – P. Ciudad, S. Bustos, A. Forte, M. Huayllani, O. Manrique, H. Chen, & E. Trignano (2021)

Mast cell activation syndrome – A primer for the gastroenterologist – L. Weinstock, L. Pace, A. Rezaie, L. Afrin, & G. Molderings (2020)

Mast cell activation syndrome – Proposed diagnostic criteria – C. Akin, P. Valent, & D. Metcalfe (2010)

Mast cell disorders in Ehlers-Danlos syndrome – S. Seneviratne, A. Maitland, & L. Afrin (2017)

Mast cells as regulators ok skin inflammation and immunity – I. Harvima & G. Nils (2011)

Metabolic and immunological phenotype of rare lipomatoses: Dercum’s disease and Roch-Leri mesosomatic lipomatosis – M. Lemaitre, B. Chevalier, A. Jannin, K. Le Mapihan, S. Boury, G. Lion, M. Labalette, & M. Vantyghem (2021)

Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction – Z. Malekpour-Dehkordi, S. Teimourian, M. Nourbakhsh, Y. Naghiaee, R. Sharifi, & J. Mohiti-Ardakani (2019)

Minocycline – Far beyond an antibiotic – N. Garrido-Mesa, A. Zarzuelo, & J. Galvez (2013)

Obesity as a risk factor for tendinopathy – A systemic review – F. Franceschi, R. Papalia, M. Paciotti, E. Franceschetti, A. Di Martino, N. Maffulli, & V. Denaro (2014)

Obesity stigma – Important considerations for public health – R. Puhl & C. Heuer (2010)

Operative treatment of lymphedema using suction-assisted lipectomy – A. Greene & R. Maclellan (2016)

Orange juice neutralizes the proinflammatory effect of a high-fat high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression – H. Ghanim, C. Sia, M. Upadhyay, K. Korzeniewski, P. Viswanathan, S. Abuaysheh, … & P. Dandona (2010)

Osteopathic manipulative treatment as a useful adjunctive tool for pneumonia – S. Yao, J. Hassani, M. Gagne, G. George, & W. Gilliar (2014)

Osteopathic manipulative treatment – Novel application to dermatological disease – S. Campbell, R. Winkelmann, & S. Walkowski (2012)

Pathophysiological mechanisms involved in nonalcoholic steatohepatitis and novel potential therapeutic targets – F. Higuera-de la Tijera & A. Servín-Caamano (2015)

Photobiomics – Can light, including photobiomodulation, alter the microbiome? – A. Liebert, B. Bicknell, D. Johnstone, L. Gordon, H. Kiat, & M. Hamblin (2019)

Pioglitazone enhances small-sized adipocyte proliferation in subcutaneous adipose tissue – K. Kajita, I. Mori, T. Hanamoto, T. Ikeda, K. Fujioka, M. Yamauchi, … & T. Ishizuka (2012)

Postural orthostatic tachycardia syndrome – Priorities for POTS care and research from a 2019 NIH expert consensus meeting – Part 2 – S. Raj, K. Bourne, L. Stiles, M. Miglis, M. Cortez, A. Miller, … & S. Verninoa (2021)

Prevalence of functional GI diseases and pelvic floor symptoms in Marfan syndrome and Ehlers-Danlos syndrome – A national cohort study – J. Nee, S. Kilaru, J. Kelley, S. Oza, W. Hirsch, S. Ballou, … & J. Wolf (2019)

Redox state and methods to evaluate oxidative stress in liver damage – From bench to bedside – J. Arauz, E. Ramos-Tovar, & P. Muriel (2016)

Reducing calorie intake may hot help you lose body weight – D. Benton & H. Young (2017)

Role of lymphoscintigraphy in diagnosis and management of patients with leg swelling of unclear etiology – T. Kalawat, R. Chittoria, P. Reddy, B. Suneetha, R. Narayan, & P. Ravi (2012)

Role of NADPH oxidases in the redox biology of liver fibrosis – E. Crosas-Molist & I. Fabregat (2015)

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease – Z. Chena, R. Tiana, Z. Shea, J. Caia, & H. Li (2020)

Rule of four – A simple and safe formula for tumescent anesthesia in dermatologic surgical procedures – A. dos Reis Gadelha & T. Lima de Miranda Leao (2009)

Selling sickness – The pharmaceutical industry and disease mongering – R. Moynihan, I. Heath, & D. Henry (2002)

Subcutaneous lymphatic drainage for palliation of severe refractory lymphedema in cancer patients – J. Jacobsen & C. Blinderman (2011)

Successful treatment of Dercum’s disease by transcutaneous electrical stimulation – S. Martinenghi, A. Caretto, C. Losio, M. Scavini, & E. Bosi (2015)

Suction assisted protein lipectomy (SAPL) even for the treatment of chronic fibrotic and scarified lower extremity lymphedema – M. Lee, L. Perry, & J. Granzow (2016)

Surgical Treatment of Lymphedema – M. Schaverien & C. Coroneos (2019)

The alveolar macrophages in asthma – A double-edged sword – J. Balhara & A. Gounni (2012)

The effect of caffeine and albuterol on body composition and metabolic rate – A. Liu, K. Arceneaux III, J. Chu, G. Jacob Jr., A. Schreiber, R. Tipton, & S. Primeaux (2015)

The lowdown on low-dose naltrexone – N. Shabeeb (2020)

The mechanism of action of gabapentin in neuropathic pain – J. Gaillie & I. Power (2006)

The pros and cons of phytoestrogens – H. Patisaul & W. Jefferson (2010)

The use of low-dose naltrexone as a novel anti-inflammatory treatment for chronic pain – J. Younger, L. Parkitny, & D. McLain (2014)

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone – M. McCann, C. Yeung, M. Pest, A. Ratneswaran, S. Pollmann, D. Holdsworth, … & C. Seguin (2017)

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